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Tip Cells in Angiogenesis

Dallinga, M. G., Boas, S. E. M, Klaassen, I., Merks, R. M. H., van Noorden, C. J., & Schlingemann, R. O. (2015). Tip Cells in Angiogenesis. eLS, 1–10. doi:10.1002/9780470015902.a0025977

In angiogenesis, the process in which blood vessel sprouts grow out from a pre-existing vascular network, the so-called endothelial tip cells play an essential role. Tip cells are the leading cells of the sprouts; they guide following endothelial cells and sense their environment for guidance cues. Because of this essential role, the tip cells are a potential therapeutic target for anti-angiogenic therapies, which need to be developed for dis- eases such as cancer and major eye diseases. The potential of anti-tip cell therapies is now widely recognised, and the surge in research this has caused has led to improved insights in the func- tion and regulation of tip cells, as well as the development of novel in vitro and in silico models. These new models in particular will help under- stand essential mechanisms in tip cell biology and may eventually lead to new or improved therapies to prevent blindness or cancer spread. [ doi:10.1002/9780470015902.a0025977 ]

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