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Multiscale analysis of morphogenesis

Claudiu-Cristi Antonovici, Sonja E.M. Boas, Elisabeth G. Rens, Hannan Tahir, Roeland M.H. Merks (in press). Multiscale Analysis of Morphogenesis. In: Ralph A. Bradshaw and Philip Stahl (Eds.) Encyclopedia of Cell Biology, Section 4, Doug Lauffenburger (Ed.) Systems Cell Biology. Elsevier (Amsterdam). In press.

How does the genetic information encoded in the DNA direct the growth and form of multicellular organisms? The genome directs a cell`s biophysical properties and its response to signals from adjacent cells. To analyse how these cell behaviours drive embryogenesis, insights into the collective behaviour of multicellular aggregates is crucial. This article describes computational approaches to the study of collective cell behaviour. Four examples (cell sorting, angiogenesis, somitogenesis, and root development) illustrate how insights into collective cell behaviour are incorporated into experimental studies to unravel the mechanisms of development. [ publisher's website ]